the only consideration is how/where you mount it in the bed. A few folks mount it dead in the center, but in my opinion, that makes the bed pretty much worthless for hauling anything. You can stand the tire up on end along a side, which isn't bad. For me, I just let it float (not really mounted) and just run tie downs to keep it from moving around when I'm on the trail.. then again, I don't really worry about anybody stealing it out of my bed.
I'm outside your window watching you read this.